Marks and Spencer says 950 jobs are at risk as part of plans to reduce store management and head office roles.
The Isle of Wight has two M&S stores, one in Newport and one in Cowes.
The retailer would not comment on individual shops, but says it wants to create a "leaner" management structure.
M&S is proposing to remove role duplication, provide clearer leadership accountabilities and free up its retail teams to focus more on the customer.
Sacha Berendji, Director of Retail, Operations and Property at M&S said:
“Our proposals reflect an important next step in our Never the Same Again programme to accelerate our transformation and become a stronger, leaner and more resilient business. Through the crisis we have seen how we can work faster and more flexibly by empowering store teams and it's essential that we embed that way of working. Our priority now is to support all those affected through the consultation process and beyond.”
M&S has now started collective consultation with its employee representative group and has set out its intention to first offer voluntary redundancy to affected colleagues.