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Ben Youngs admitted England's poor start had cost England dear as they slipped to series defeat in South Africa.
Willem Alberts, Bismarck du Plessis and Francois Hougaard scored early tries for the Springboks as England were overrun at Ellis Park.
But Youngs crossed twice as England put themselves in sight of an unlikely victory after trailing 28-10.
However JP Pietersen ended the comeback with a late try.
Afterwards Youngs told Sky Sports: 'The first 20 mins killed us unfortunately and we were always playing catch-up. Great spirit by the boys but at the end it didn't count for much.
'Now we've lost the series but we've got one more big effort next week. It was a great effort and great heart from the boys but we can't give them the first 20 minutes like that and be playing catch-up in a game like this.'
