Henrietta Knight, trainer of three times Cheltenham Gold Cup winner Best Mate, has announced her retirement from horse racing.
The decision comes seven months after her husband, three-times champion jockey Terry Biddlecombe, suffered a stroke.
The 65-year-old had over 700 winners in her career and will give up her National Hunt licence at the end of the month.
Trainer Mick Channon will assume control of the majority of Knight's horses.
Best Mate won three consecutive Gold Cups at the Cheltenham Festival between 2002-04
Knight also trained Edredon Bleu, who won the Queen Mother Champion Chase at Cheltenham in 2000 and the King George VI Chase at Kempton in 2003.
Knight said: "I am hugely grateful for the backing that I have received over the past years from my family, my loyal owners, my dedicated staff and from numerous top jockeys."
"Likewise the press and media have always been tremendously supportive. I would like to thank everybody who has helped me enjoy so many happy days."